5L0I

Human metavinculin MVt R975W cardiomyopathy-associated mutant (residues 959-1134)

Summary for 5L0I

Entry DOI	10.2210/pdb5l0i/pdb
Descriptor	Vinculin, GLYCEROL, SODIUM ION, ... (4 entities in total)
Functional Keywords	5-helix bundle, cytoskeletal protein, cell adhesion, cardiomyopathy
Biological source	Homo sapiens (Human)
Cellular location	Cell membrane ; Peripheral membrane protein ; Cytoplasmic side : P18206
Total number of polymer chains	1
Total formula weight	19763.80
Authors	Chinthalapudi, K.,Izard, T. (deposition date: 2016-07-27, release date: 2016-08-31, Last modification date: 2023-10-04)
Primary citation	Chinthalapudi, K.,Rangarajan, E.S.,Brown, D.T.,Izard, T. Differential lipid binding of vinculin isoforms promotes quasi-equivalent dimerization. Proc.Natl.Acad.Sci.USA, 113:9539-9544, 2016 Cited by PubMed: 27503891 DOI: 10.1073/pnas.1600702113 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.45 Å)

Structure validation