5KNV
E coli hypoxanthine guanine phosphoribosyltransferase in complexed with 9-[(N-Phosphonoethyl-N-phosphonobutyl)-2-aminoethyl]-hypoxanthine
Summary for 5KNV
Entry DOI | 10.2210/pdb5knv/pdb |
Related | 5KNP 5KNQ 5KNR 5KNS 5KNT 5KNU 5KNX 5KNY |
Descriptor | Hypoxanthine-guanine phosphoribosyltransferase, 2-[2-(6-oxidanylidene-1~{H}-purin-9-yl)ethyl-(4-phosphonobutyl)amino]ethylphosphonic acid, MAGNESIUM ION, ... (4 entities in total) |
Functional Keywords | acyclic nucleoside phosphonate, echprt, phosphoribosyltransferase, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Escherichia coli |
Total number of polymer chains | 2 |
Total formula weight | 42182.93 |
Authors | Eng, W.S.,Keough, D.T.,Hockova, D.,Janeba, Z. (deposition date: 2016-06-28, release date: 2017-07-19, Last modification date: 2023-09-27) |
Primary citation | Eng, W.S.,Hockova, D.,Spacek, P.,Baszczynski, O.,Janeba, Z.,Naesens, L.,Keough, D.T.,Guddat, L.W. Crystal Structures of Acyclic Nucleoside Phosphonates in Complex with Escherichia coli Hypoxanthine Phosphoribosyltransferase Chemistryselect, 1:6267-6276, 2016 Cited by DOI: 10.1002/slct.201601679PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.861 Å) |
Structure validation
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