5KNR

E. coli HPRT in complexed with 9-[(N-phosphonoethyl-N-phosphonoethoxyethyl)-2-aminoethyl]-guanine

Summary for 5KNR

Entry DOI	10.2210/pdb5knr/pdb
Related	5KNP 5KNQ 5KNS 5KNT 5KNU 5KNV 5KNX 5KNY
Descriptor	Hypoxanthine-guanine phosphoribosyltransferase, (2-{[2-(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)ethyl][2-(2-phosphonoethoxy)ethyl]amino}ethyl)phosphonic acid, MAGNESIUM ION, ... (4 entities in total)
Functional Keywords	inhibitor, complex, phosphoribosyltransferase, transferase-inhibitor complex, transferase/inhibitor
Biological source	Escherichia coli
Total number of polymer chains	2
Total formula weight	42220.65
Authors	Eng, W.S.,Keough, D.T.,Hockova, D.,Janeba, Z. (deposition date: 2016-06-28, release date: 2017-07-19, Last modification date: 2023-09-27)
Primary citation	Eng, W.S.,Hockova, D.,Spacek, P.,Baszczynski, O.,Janeba, Z.,Naesens, L.,Keough, D.T.,Guddat, L.W. Crystal Structures of Acyclic Nucleoside Phosphonates in Complex with Escherichia coli Hypoxanthine Phosphoribosyltransferase Chemistryselect, 1:6267-6276, 2016 Cited by DOI: 10.1002/slct.201601679 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.864 Å)

Structure validation