5KNQ

Crystal structure of Mycobacterium tuberculosis hypoxanthine guanine phosphoribosyltransferase in complex with [3S,4R]-(4-(Guanin-9-yl)pyrrolidin-3-yl)oxymethanephosphonic acid and pyrophosphate

5KNQ の概要

• エントリーDOI: 10.2210/pdb5knq/pdb
• 関連するPDBエントリー: 5KNP 5KNR 5KNS 5KNT 5KNU 5KNV 5KNX 5KNY
• 分子名称: Hypoxanthine-guanine phosphoribosyltransferase, [(3~{S},4~{R})-4-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)pyrrolidin-3-yl]oxymethylphosphonic acid, MAGNESIUM ION, ... (5 entities in total)
• 機能のキーワード: phosphoribosyltransferase, inhibitor, complex, pyrrolidne nucleoside phosphonate, transferase-inhibitor complex, transferase/inhibitor
• 由来する生物種: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
• 細胞内の位置: Cytoplasm : P9WHQ9
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 94098.43

構造登録者

Eng, W.S.,Rejman, D.,Keough, D.T.,Guddat, L.W. (登録日: 2016-06-28, 公開日: 2017-09-20, 最終更新日: 2023-09-27)

• 主引用文献: Eng, W.S.,Rejman, D.,Keough, D.T.,Guddat, L.W.; Crystal structure of Mycobacterium tuberculosis hypoxanthine guanine phosphoribosyltransferase in complex with pyrrolidine nucleoside phosphonate; To Be Published,

実験手法

X-RAY DIFFRACTION (2.553 Å)