5KGN

1.95A resolution structure of independent phosphoglycerate mutase from C. elegans in complex with a macrocyclic peptide inhibitor (2d)

5KGN の概要

• エントリーDOI: 10.2210/pdb5kgn/pdb
• 関連するPDBエントリー: 5KGL 5KGM
• 分子名称: 2,3-bisphosphoglycerate-independent phosphoglycerate mutase, macrocyclic peptide inhibitor, CHLORIDE ION, ... (8 entities in total)
• 機能のキーワード: metal binding, coupled enzyme assay, hts, structure activity relationship, rapid systems, high throughput enzymology, isomerase
• 由来する生物種: Caenorhabditis elegans; 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 120870.56

構造登録者

Lovell, S.,Mehzabeen, N.,Battaile, K.P.,Yu, H.,Dranchak, P.,MacArthur, R.,Li, Z.,Carlow, T.,Suga, H.,Inglese, J. (登録日: 2016-06-13, 公開日: 2017-04-05, 最終更新日: 2023-09-27)

• 主引用文献: Yu, H.,Dranchak, P.,Li, Z.,MacArthur, R.,Munson, M.S.,Mehzabeen, N.,Baird, N.J.,Battalie, K.P.,Ross, D.,Lovell, S.,Carlow, C.K.,Suga, H.,Inglese, J.; Macrocycle peptides delineate locked-open inhibition mechanism for microorganism phosphoglycerate mutases.; Nat Commun, 8:14932-14932, 2017; PubMed: 28368002; DOI: 10.1038/ncomms14932

実験手法

X-RAY DIFFRACTION (1.95 Å)