5KAP
Trypanosome brucei Hypoxanthine-guanine phosphoribosyltranferase in complex with a 9-(4-(phosphonobutil)hypoxanthine
Summary for 5KAP
Entry DOI | 10.2210/pdb5kap/pdb |
Related | 5JSQ 5JV5 5K51 5KAM |
Descriptor | Hypoxanthine-guanine phosphoribosyltransferase, 4-(6-oxidanylidene-1~{H}-purin-9-yl)butylphosphonic acid, SULFATE ION, ... (5 entities in total) |
Functional Keywords | inhibitor, complex, dimer, enzyme, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Trypanosoma brucei brucei |
Cellular location | Cytoplasm: Q07010 |
Total number of polymer chains | 2 |
Total formula weight | 49421.97 |
Authors | Teran, D.,Guddat, L. (deposition date: 2016-06-01, release date: 2016-11-09, Last modification date: 2023-09-27) |
Primary citation | Teran, D.,Hockova, D.,Cesnek, M.,Zikova, A.,Naesens, L.,Keough, D.T.,Guddat, L.W. Crystal structures and inhibition of Trypanosoma brucei hypoxanthine-guanine phosphoribosyltransferase. Sci Rep, 6:35894-35894, 2016 Cited by PubMed: 27786284DOI: 10.1038/srep35894 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.95 Å) |
Structure validation
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