5KAP

Trypanosome brucei Hypoxanthine-guanine phosphoribosyltranferase in complex with a 9-(4-(phosphonobutil)hypoxanthine

Summary for 5KAP

• Entry DOI: 10.2210/pdb5kap/pdb
• Related: 5JSQ 5JV5 5K51 5KAM
• Descriptor: Hypoxanthine-guanine phosphoribosyltransferase, 4-(6-oxidanylidene-1~{H}-purin-9-yl)butylphosphonic acid, SULFATE ION, ... (5 entities in total)
• Functional Keywords: inhibitor, complex, dimer, enzyme, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Trypanosoma brucei brucei
• Cellular location: Cytoplasm: Q07010
• Total number of polymer chains: 2
• Total formula weight: 49421.97

Authors

Teran, D.,Guddat, L. (deposition date: 2016-06-01, release date: 2016-11-09, Last modification date: 2023-09-27)

• Primary citation: Teran, D.,Hockova, D.,Cesnek, M.,Zikova, A.,Naesens, L.,Keough, D.T.,Guddat, L.W.; Crystal structures and inhibition of Trypanosoma brucei hypoxanthine-guanine phosphoribosyltransferase.; Sci Rep, 6:35894-35894, 2016; PubMed: 27786284; DOI: 10.1038/srep35894

Experimental method

X-RAY DIFFRACTION (2.95 Å)