5JSQ

Trypanosome brucei Hypoxanthine-guanine phosphoribosyltranferase in complex with a 9-[7-(phosphonoheptyl]guanine

Summary for 5JSQ

Entry DOI	10.2210/pdb5jsq/pdb
Related	5JV5 5K51 5KAM 5KAP
Descriptor	hypoxanthine-guanine phosphoribosyltranferase, [6-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)hexyl]phosphonic acid, DI(HYDROXYETHYL)ETHER, ... (7 entities in total)
Functional Keywords	inhibitor, complex, dimer, enzyme, transferase
Biological source	Trypanosoma brucei brucei
Cellular location	Cytoplasm: Q07010
Total number of polymer chains	2
Total formula weight	49803.34
Authors	Teran, D.,Guddat, L. (deposition date: 2016-05-09, release date: 2016-11-09, Last modification date: 2023-09-27)
Primary citation	Teran, D.,Hockova, D.,Cesnek, M.,Zikova, A.,Naesens, L.,Keough, D.T.,Guddat, L.W. Crystal structures and inhibition of Trypanosoma brucei hypoxanthine-guanine phosphoribosyltransferase. Sci Rep, 6:35894-35894, 2016 Cited by PubMed: 27786284 DOI: 10.1038/srep35894 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.503 Å)

Structure validation