5K4L

Crystal structure of KDM5A in complex with a naphthyridone inhibitor

Summary for 5K4L

Entry DOI	10.2210/pdb5k4l/pdb
Descriptor	Lysine-specific demethylase 5A, Unknown Peptide, NICKEL (II) ION, ... (6 entities in total)
Functional Keywords	epigenetics, demethylase, jumonji, inhibitor, cancer, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
Biological source	Homo sapiens (Human) More
Cellular location	Nucleus, nucleolus : P29375
Total number of polymer chains	4
Total formula weight	183991.47
Authors	Kiefer, J.R.,Vinogradova, M.V. (deposition date: 2016-05-20, release date: 2016-08-10, Last modification date: 2016-09-07)
Primary citation	Labadie, S.S.,Dragovich, P.S.,Cummings, R.T.,Deshmukh, G.,Gustafson, A.,Han, N.,Harmange, J.C.,Kiefer, J.R.,Li, Y.,Liang, J.,Liederer, B.M.,Liu, Y.,Manieri, W.,Mao, W.,Murray, L.,Ortwine, D.F.,Trojer, P.,VanderPorten, E.,Vinogradova, M.,Wen, L. Design and evaluation of 1,7-naphthyridones as novel KDM5 inhibitors. Bioorg.Med.Chem.Lett., 26:4492-4496, 2016 Cited by PubMed: 27499454 DOI: 10.1016/j.bmcl.2016.07.070 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.179 Å)

Structure validation