5K4L
Crystal structure of KDM5A in complex with a naphthyridone inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Lysine-specific demethylase 5A | polymer | 790 | 90703.9 | 2 | UniProt (P29375) Pfam (PF02375) Pfam (PF01388) Pfam (PF00628) Pfam (PF02373) Pfam (PF21323) Pfam (PF02928) In PDB | Homo sapiens (Human) | Histone demethylase JARID1A,Jumonji/ARID domain-containing protein 1A,Retinoblastoma-binding protein 2,RBBP-2 |
| 2 | F, G | Unknown Peptide | polymer | 10 | 869.1 | 2 | Homo sapiens (Human) | ||
| 3 | A, B | NICKEL (II) ION | non-polymer | 58.7 | 2 | Chemie (NI) | |||
| 4 | A, B | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 5 | A, B | ~{N}-ethyl-4-oxidanyl-2-oxidanylidene-1~{H}-1,7-naphthyridine-3-carboxamide | non-polymer | 233.2 | 2 | Chemie (6QN) | |||
| 6 | water | water | 18.0 | 20 | Chemie (HOH) |
Sequence modifications
A, B: 12 - 797 (UniProt: P29375)
| PDB | External Database | Details |
|---|---|---|
| Ser 11 | - | expression tag |
| Gly 798 | - | expression tag |
| Asn 799 | - | expression tag |
| Ser 800 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 183146.0 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 845.5 | |
| All* | Total formula weight | 183991.5 |
