5K4L

Crystal structure of KDM5A in complex with a naphthyridone inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
B	0003677	molecular_function	DNA binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue NI A 901

Chain	Residue
A	HIS483
A	GLU485
A	HIS571
A	6QN904

---

site_id	AC2
Number of Residues	3
Details	binding site for residue ZN A 902

Chain	Residue
A	CYS676
A	CYS679
A	CYS699

---

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN A 903

Chain	Residue
A	CYS692
A	CYS709
A	CYS690
A	SER691

---

site_id	AC4
Number of Residues	11
Details	binding site for residue 6QN A 904

Chain	Residue
A	TYR472
A	SER478
A	PHE480
A	HIS483
A	GLU485
A	ASN493
A	LYS501
A	TRP503
A	HIS571
A	ASN575
A	NI901

---

site_id	AC5
Number of Residues	4
Details	binding site for residue NI B 901

Chain	Residue
B	HIS483
B	GLU485
B	HIS571
B	6QN904

---

site_id	AC6
Number of Residues	5
Details	binding site for residue ZN B 902

Chain	Residue
B	CYS676
B	ALA678
B	CYS679
B	CYS699
B	HIS702

---

site_id	AC7
Number of Residues	4
Details	binding site for residue ZN B 903

Chain	Residue
B	CYS690
B	CYS692
B	CYS707
B	CYS709

---

site_id	AC8
Number of Residues	11
Details	binding site for residue 6QN B 904

Chain	Residue
B	TYR472
B	VAL473
B	SER479
B	PHE480
B	HIS483
B	ASN493
B	LYS501
B	TRP503
B	HIS571
B	ASN575
B	NI901

---

Functional Information from PROSITE/UniProt

site_id	PS01359
Number of Residues	45
Details	ZF_PHD_1 Zinc finger PHD-type signature. CmfCgrgnnedkl....................................LlCdg..Cdds.YHtfClipplpdvpkgd.................................WrCpkC

Chain	Residue	Details
A	CYS296-CYS340

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	82
Details	Domain: {"description":"JmjN","evidences":[{"source":"PROSITE-ProRule","id":"PRU00537","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	180
Details	Domain: {"description":"ARID","evidences":[{"source":"PROSITE-ProRule","id":"PRU00355","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	332
Details	Domain: {"description":"JmjC","evidences":[{"source":"PROSITE-ProRule","id":"PRU00538","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	104
Details	Zinc finger: {"description":"C5HC2","evidences":[{"source":"PubMed","id":"27214401","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27499454","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5CEH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	Motif: {"description":"GSGFP motif","evidences":[{"source":"UniProtKB","id":"Q3UXZ9","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26645689","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27427228","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00538","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"26645689","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27214401","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27427228","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27499454","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26645689","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27214401","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27427228","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27499454","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---