5JYP
Allosteric inhibition of Kidney Isoform of Glutaminase
Summary for 5JYP
Entry DOI | 10.2210/pdb5jyp/pdb |
Related | 5JYO |
Descriptor | Glutaminase kidney isoform, mitochondrial, 2-phenyl-~{N}-[5-[(1~{S},3~{S})-3-[5-(2-phenylethanoylamino)-1,3,4-thiadiazol-2-yl]cyclohexyl]-1,3,4-thiadiazol-2-yl]ethanamide (3 entities in total) |
Functional Keywords | kga, gac, allosteric inhibition, warburg effect, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 37153.40 |
Authors | Ramachandran, S.,Sivaraman, J. (deposition date: 2016-05-15, release date: 2016-08-03, Last modification date: 2023-11-08) |
Primary citation | Ramachandran, S.,Pan, C.Q.,Zimmermann, S.C.,Duvall, B.,Tsukamoto, T.,Low, B.C.,Sivaraman, J. Structural basis for exploring the allosteric inhibition of human kidney type glutaminase. Oncotarget, 7:57943-57954, 2016 Cited by PubMed: 27462863DOI: 10.18632/oncotarget.10791 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.74 Å) |
Structure validation
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