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5JYP

Allosteric inhibition of Kidney Isoform of Glutaminase

Summary for 5JYP
Entry DOI10.2210/pdb5jyp/pdb
Related5JYO
DescriptorGlutaminase kidney isoform, mitochondrial, 2-phenyl-~{N}-[5-[(1~{S},3~{S})-3-[5-(2-phenylethanoylamino)-1,3,4-thiadiazol-2-yl]cyclohexyl]-1,3,4-thiadiazol-2-yl]ethanamide (3 entities in total)
Functional Keywordskga, gac, allosteric inhibition, warburg effect, hydrolase
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight37153.40
Authors
Ramachandran, S.,Sivaraman, J. (deposition date: 2016-05-15, release date: 2016-08-03, Last modification date: 2023-11-08)
Primary citationRamachandran, S.,Pan, C.Q.,Zimmermann, S.C.,Duvall, B.,Tsukamoto, T.,Low, B.C.,Sivaraman, J.
Structural basis for exploring the allosteric inhibition of human kidney type glutaminase.
Oncotarget, 7:57943-57954, 2016
Cited by
PubMed: 27462863
DOI: 10.18632/oncotarget.10791
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.74 Å)
Structure validation

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