5JYP

Allosteric inhibition of Kidney Isoform of Glutaminase

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Glutaminase kidney isoform, mitochondrial	polymer	333	36634.7	1	UniProt (O94925) Pfam (PF04960)	Homo sapiens (Human)	GLS,K-glutaminase,L-glutamine amidohydrolase
2	B (A)	2-phenyl-~{N}-[5-[(1~{S},3~{S})-3-[5-(2-phenylethanoylamino)-1,3,4-thiadiazol-2-yl]cyclohexyl]-1,3,4-thiadiazol-2-yl]ethanamide	non-polymer		518.7	1	Chemie (ZBS)
3	C (A)	water	water		18.0	16	Chemie (HOH)

Sequence modifications

A: 221 - 533 (UniProt: O94925)

PDB	External Database	Details
Met 201	-	expression tag
Gly 202	-	expression tag
Ser 203	-	expression tag
Ser 204	-	expression tag
His 205	-	expression tag
His 206	-	expression tag
His 207	-	expression tag
His 208	-	expression tag
His 209	-	expression tag
His 210	-	expression tag
Ser 211	-	expression tag
Ser 212	-	expression tag
Gly 213	-	expression tag
Leu 214	-	expression tag
Val 215	-	expression tag
Pro 216	-	expression tag
Arg 217	-	expression tag
Gly 218	-	expression tag
Ser 219	-	expression tag
Met 220	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	36634.7
Non-Polymers*	Number of molecules	1
	Total formula weight	518.7
All*	Total formula weight	37153.4

*Water molecules are not included.