5JYP

Allosteric inhibition of Kidney Isoform of Glutaminase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004359	molecular_function	glutaminase activity
A	0006541	biological_process	glutamine metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	binding site for residue ZBS A 601

Chain	Residue
A	LYS320
A	LYS320
A	LEU321
A	LEU321
A	PHE322
A	PHE322
A	LEU323
A	LEU323
A	TYR394

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22049910","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22538822","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24451979","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3CZD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UNW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3VP0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3VP1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22049910","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22538822","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24451979","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3CZD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UNW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3VP1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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