5JYO
Allosteric inhibition of Kidney Isoform of Glutaminase
Summary for 5JYO
Entry DOI | 10.2210/pdb5jyo/pdb |
Related | 5JYP |
Descriptor | Glutaminase kidney isoform, mitochondrial, 2-(pyridin-2-yl)-N-(5-{4-[6-({[3-(trifluoromethoxy)phenyl]acetyl}amino)pyridazin-3-yl]butyl}-1,3,4-thiadiazol-2-yl)acetamide (3 entities in total) |
Functional Keywords | kga, gac, allosteric inhibition, warburg effect, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 8 |
Total formula weight | 295364.23 |
Authors | Sivaraman, J.,Jayaraman, S. (deposition date: 2016-05-15, release date: 2016-08-03, Last modification date: 2023-11-08) |
Primary citation | Ramachandran, S.,Pan, C.Q.,Zimmermann, S.C.,Duvall, B.,Tsukamoto, T.,Low, B.C.,Sivaraman, J. Structural basis for exploring the allosteric inhibition of human kidney type glutaminase. Oncotarget, 7:57943-57954, 2016 Cited by PubMed: 27462863DOI: 10.18632/oncotarget.10791 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.098 Å) |
Structure validation
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