5JYO
Allosteric inhibition of Kidney Isoform of Glutaminase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004359 | molecular_function | glutaminase activity |
| A | 0006541 | biological_process | glutamine metabolic process |
| B | 0004359 | molecular_function | glutaminase activity |
| B | 0006541 | biological_process | glutamine metabolic process |
| C | 0004359 | molecular_function | glutaminase activity |
| C | 0006541 | biological_process | glutamine metabolic process |
| D | 0004359 | molecular_function | glutaminase activity |
| D | 0006541 | biological_process | glutamine metabolic process |
| E | 0004359 | molecular_function | glutaminase activity |
| E | 0006541 | biological_process | glutamine metabolic process |
| F | 0004359 | molecular_function | glutaminase activity |
| F | 0006541 | biological_process | glutamine metabolic process |
| G | 0004359 | molecular_function | glutaminase activity |
| G | 0006541 | biological_process | glutamine metabolic process |
| H | 0004359 | molecular_function | glutaminase activity |
| H | 0006541 | biological_process | glutamine metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | binding site for residue 63J D 601 |
| Chain | Residue |
| D | LYS320 |
| E | LEU323 |
| E | TYR394 |
| D | LEU321 |
| D | PHE322 |
| D | LEU323 |
| D | GLU325 |
| D | TYR394 |
| E | LYS320 |
| E | LEU321 |
| E | PHE322 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | binding site for residue 63J C 601 |
| Chain | Residue |
| B | LYS320 |
| B | LEU321 |
| B | PHE322 |
| B | LEU323 |
| B | TYR394 |
| C | LYS320 |
| C | LEU321 |
| C | PHE322 |
| C | LEU323 |
| C | TYR394 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | binding site for residue 63J F 601 |
| Chain | Residue |
| F | LYS320 |
| F | LEU321 |
| F | PHE322 |
| F | LEU323 |
| F | ASN324 |
| F | TYR394 |
| H | LEU321 |
| H | PHE322 |
| H | LEU323 |
| H | TYR394 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | binding site for residue 63J F 602 |
| Chain | Residue |
| A | LEU321 |
| A | PHE322 |
| A | LEU323 |
| A | ASN324 |
| A | TYR394 |
| G | LYS320 |
| G | LEU321 |
| G | PHE322 |
| G | LEU323 |
| G | ASN324 |
| G | TYR394 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 48 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22049910","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22538822","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24451979","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3CZD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UNW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3VP0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3VP1","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22049910","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22538822","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24451979","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3CZD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UNW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3VP1","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
