5JWB

Structure of NDH2 from plasmodium falciparum in complex with NADH

Summary for 5JWB

• Entry DOI: 10.2210/pdb5jwb/pdb
• Related: 5JWA 5JWC
• Descriptor: Type II NADH:ubiquinone oxidoreductase, FLAVIN-ADENINE DINUCLEOTIDE, MAGNESIUM ION, ... (8 entities in total)
• Functional Keywords: pfndh2, nadh, membrane protein-inhibitor complex, membrane protein/inhibitor
• Biological source: Plasmodium falciparum (isolate 3D7)
• Total number of polymer chains: 2
• Total formula weight: 126661.81

Authors

Yu, Y.,Li, X.L. (deposition date: 2016-05-12, release date: 2017-03-29, Last modification date: 2023-11-08)

• Primary citation: Yang, Y.,Yu, Y.,Li, X.,Li, J.,Wu, Y.,Yu, J.,Ge, J.,Huang, Z.,Jiang, L.,Rao, Y.,Yang, M.; Target Elucidation by Cocrystal Structures of NADH-Ubiquinone Oxidoreductase of Plasmodium falciparum (PfNDH2) with Small Molecule To Eliminate Drug-Resistant Malaria; J. Med. Chem., 60:1994-2005, 2017; PubMed: 28195463; DOI: 10.1021/acs.jmedchem.6b01733

Experimental method

X-RAY DIFFRACTION (2.7 Å)