5JMC

Receptor binding domain of Botulinum neurotoxin A in complex with rat SV2C

Summary for 5JMC

• Entry DOI: 10.2210/pdb5jmc/pdb
• Related: 5JLV
• Descriptor: Botulinum neurotoxin type A, Synaptic vesicle glycoprotein 2C (3 entities in total)
• Functional Keywords: hydrolase
• Biological source: Clostridium botulinum; More
• Total number of polymer chains: 8
• Total formula weight: 259976.98

Authors

Yao, G.,Zhang, S.,Mahrhold, S.,Lam, K.,Stern, D.,Bagramyan, K.,Perry, K.,Kalkum, M.,Rummel, A.,Dong, M.,Jin, R. (deposition date: 2016-04-28, release date: 2016-06-15, Last modification date: 2023-09-27)

• Primary citation: Yao, G.,Zhang, S.,Mahrhold, S.,Lam, K.H.,Stern, D.,Bagramyan, K.,Perry, K.,Kalkum, M.,Rummel, A.,Dong, M.,Jin, R.; N-linked glycosylation of SV2 is required for binding and uptake of botulinum neurotoxin A.; Nat.Struct.Mol.Biol., 23:656-662, 2016; PubMed: 27294781; DOI: 10.1038/nsmb.3245

Experimental method

X-RAY DIFFRACTION (2.64 Å)