5JMC

Receptor binding domain of Botulinum neurotoxin A in complex with rat SV2C

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C, E, G (A, C, E, G)	Botulinum neurotoxin type A	polymer	433	50472.2	4	UniProt (P10845) Pfam (PF07953) Pfam (PF07951) UniProt (by SIFTS) (P0DPI1)	Clostridium botulinum	BoNT/A,Bontoxilysin-A,BOTOX
2	B, D, F, H (B, D, F, H)	Synaptic vesicle glycoprotein 2C	polymer	124	14522.1	4	UniProt (Q9Z2I6) Pfam (PF13599)	Rattus norvegicus (Rat)	Synaptic vesicle protein 2C
3	I, J, K, L, M... (A, B, C, D, E...)	water	water		18.0	162	Chemie (HOH)

Sequence modifications

A, C, E, G: 872 - 1296 (UniProt: P10845)

PDB	External Database	Details
Gly 868	-	expression tag
Ser 869	-	expression tag
His 870	-	expression tag
Met 871	-	expression tag
Ala 1158	Thr 1158	engineered mutation
Leu 1297	-	expression tag
Val 1298	-	expression tag
Pro 1299	-	expression tag
Arg 1300	-	expression tag

B, D, F, H: 455 - 577 (UniProt: Q9Z2I6)

PDB	External Database	Details
Gly 454	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	259977.0
All*	Total formula weight	259977.0

*Water molecules are not included.