5IZ0
RORgamma in complex with agonist BIO592 and Coactivator EBI96
Summary for 5IZ0
Entry DOI | 10.2210/pdb5iz0/pdb |
Descriptor | Nuclear receptor ROR-gamma, GLU-PHE-PRO-TYR-LEU-LEU-SER-LEU-LEU-GLY-GLU-VAL-SER-PRO-GLN, N-(4-ethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl)-3,4-dimethyl-N-(2,2,2-trifluoroethyl)benzene-1-sulfonamide, ... (5 entities in total) |
Functional Keywords | rorgamma, nuclear hormone receptor, agonist, af2 helix, immune system |
Biological source | Homo sapiens (Human) More |
Cellular location | Nucleus : P51449 |
Total number of polymer chains | 8 |
Total formula weight | 130760.91 |
Authors | Marcotte, D.J. (deposition date: 2016-03-24, release date: 2016-06-15, Last modification date: 2023-09-27) |
Primary citation | Marcotte, D.J.,Liu, Y.,Little, K.,Jones, J.H.,Powell, N.A.,Wildes, C.P.,Silvian, L.F.,Chodaparambil, J.V. Structural determinant for inducing RORgamma specific inverse agonism triggered by a synthetic benzoxazinone ligand. Bmc Struct.Biol., 16:7-7, 2016 Cited by PubMed: 27246200DOI: 10.1186/s12900-016-0059-3 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.635 Å) |
Structure validation
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