5IZ0
RORgamma in complex with agonist BIO592 and Coactivator EBI96
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E, G (A, B, D, G) | Nuclear receptor ROR-gamma | polymer | 263 | 30352.0 | 4 | UniProt (P51449) Pfam (PF00104) | Homo sapiens (Human) | Nuclear receptor RZR-gamma,Nuclear receptor subfamily 1 group F member 3,RAR-related orphan receptor C,Retinoid-related orphan receptor-gamma |
| 2 | B, D, F, H (C, E, F, H) | GLU-PHE-PRO-TYR-LEU-LEU-SER-LEU-LEU-GLY-GLU-VAL-SER-PRO-GLN | polymer | 15 | 1691.9 | 4 | Homo sapiens | ||
| 3 | DA, I, R, Y (G, A, B, D) | N-(4-ethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl)-3,4-dimethyl-N-(2,2,2-trifluoroethyl)benzene-1-sulfonamide | non-polymer | 442.5 | 4 | Chemie (6F1) | |||
| 4 | AA, BA, CA, EA, FA... (D, G, A, B) | CHLORIDE ION | non-polymer | 35.5 | 23 | Chemie (CL) | |||
| 5 | JA, KA, LA, MA, NA... (A, C, B, E, D...) | water | water | 18.0 | 150 | Chemie (HOH) |
Sequence modifications
A, B, D, G: 259 - 519 (UniProt: P51449)
| PDB | External Database | Details |
|---|---|---|
| Gly 257 | - | expression tag |
| Pro 258 | - | expression tag |
| Thr 508 | - | insertion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 128175.7 | |
| Non-Polymers* | Number of molecules | 27 |
| Total formula weight | 2585.2 | |
| All* | Total formula weight | 130760.9 |
