5ISL

Linked KDM5A Jmj Domain Bound to the Inhibitor C49 (2-{[(2-{[(E)-2-(dimethylamino)ethenyl](ethyl)amino}-2-oxoethyl)amino]methyl}pyridine-4-carboxylic acid)

Summary for 5ISL

• Entry DOI: 10.2210/pdb5isl/pdb
• Related: 5IVB 5IVC 5IVE 5IVF 5IVJ 5IVV 5IVY 5IW0 5IWF
• Descriptor: Lysine-specific demethylase 5A, 2-{[(2-{[(E)-2-(dimethylamino)ethenyl](ethyl)amino}-2-oxoethyl)amino]methyl}pyridine-4-carboxylic acid, MANGANESE (II) ION, ... (6 entities in total)
• Functional Keywords: demethylase inhibition, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 38460.30

Authors

Horton, J.R.,Cheng, X. (deposition date: 2016-03-15, release date: 2016-07-27, Last modification date: 2023-09-27)

• Primary citation: Horton, J.R.,Liu, X.,Gale, M.,Wu, L.,Shanks, J.R.,Zhang, X.,Webber, P.J.,Bell, J.S.,Kales, S.C.,Mott, B.T.,Rai, G.,Jansen, D.J.,Henderson, M.J.,Urban, D.J.,Hall, M.D.,Simeonov, A.,Maloney, D.J.,Johns, M.A.,Fu, H.,Jadhav, A.,Vertino, P.M.,Yan, Q.,Cheng, X.; Structural Basis for KDM5A Histone Lysine Demethylase Inhibition by Diverse Compounds.; Cell Chem Biol, 23:769-781, 2016; PubMed: 27427228; DOI: 10.1016/j.chembiol.2016.06.006

Experimental method

X-RAY DIFFRACTION (1.694 Å)