5IPE
Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) nucleoside thiophosphoramidate catalytic product complex
Summary for 5IPE
Entry DOI | 10.2210/pdb5ipe/pdb |
Related | 1KPA 3TW2 4EQE 4EQG 4EQH 5I2E 5I2F 5IPB 5IPC 5IPD |
Descriptor | Histidine triad nucleotide-binding protein 1, 5'-S-phosphono-5'-thioguanosine, CHLORIDE ION, ... (5 entities in total) |
Functional Keywords | hint, histidine triad, hit, hydrolase |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: P49773 |
Total number of polymer chains | 2 |
Total formula weight | 28731.25 |
Authors | Maize, K.M.,Finzel, B.C. (deposition date: 2016-03-09, release date: 2017-03-15, Last modification date: 2023-09-27) |
Primary citation | Shah, R.,Maize, K.M.,Zhou, X.,Finzel, B.C.,Wagner, C.R. Caught before Released: Structural Mapping of the Reaction Trajectory for the Sofosbuvir Activating Enzyme, Human Histidine Triad Nucleotide Binding Protein 1 (hHint1). Biochemistry, 56:3559-3570, 2017 Cited by PubMed: 28691797DOI: 10.1021/acs.biochem.7b00148 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.45 Å) |
Structure validation
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