5I2E

Human Histidine Triad Nucleotide Binding Protein 1 (Hint1) with Bound Sulfamate Inhibitor 3a:3-(5-O-{[3-(1H-indol-3-yl)propanoyl]sulfamoyl}-beta-D-ribofuranosyl)-3H-imidazo[2,1-i]purine

Summary for 5I2E

Entry DOI	10.2210/pdb5i2e/pdb
Related	3TW2 4EQE 4EQG 4EQH 5I2F
Descriptor	Histidine triad nucleotide-binding protein 1, 3-(5-O-{[3-(1H-indol-3-yl)propanoyl]sulfamoyl}-beta-D-ribofuranosyl)-3H-imidazo[2,1-i]purine, GLYCEROL, ... (4 entities in total)
Functional Keywords	hint, histidine triad, hit, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm: P49773
Total number of polymer chains	2
Total formula weight	28826.01
Authors	Strom, A.M.,Finzel, B.C.,Wagner, C.R. (deposition date: 2016-02-08, release date: 2016-06-22, Last modification date: 2023-09-27)
Primary citation	Shah, R.,Strom, A.,Zhou, A.,Maize, K.M.,Finzel, B.C.,Wagner, C.R. Design, Synthesis, and Characterization of Sulfamide and Sulfamate Nucleotidomimetic Inhibitors of hHint1. Acs Med.Chem.Lett., 7:780-784, 2016 Cited by PubMed: 27563403 DOI: 10.1021/acsmedchemlett.6b00169 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation