5I2F

Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) with bound sulfamide inhibitor Bio-AMS

Summary for 5I2F

• Entry DOI: 10.2210/pdb5i2f/pdb
• Related: 3TW2 4EQE 4EQG 4EQH 5I2E
• Descriptor: Histidine triad nucleotide-binding protein 1, 1,2-ETHANEDIOL, 5'-deoxy-5'-[({5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl}sulfamoyl)amino]adenosine, ... (4 entities in total)
• Functional Keywords: hint, histidine triad, hit, hydrolase inhibitor complex, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm: P49773
• Total number of polymer chains: 2
• Total formula weight: 28888.14

Authors

Maize, K.M.,Finzel, B.C. (deposition date: 2016-02-08, release date: 2016-06-22, Last modification date: 2023-09-27)

• Primary citation: Shah, R.,Strom, A.,Zhou, A.,Maize, K.M.,Finzel, B.C.,Wagner, C.R.; Design, Synthesis, and Characterization of Sulfamide and Sulfamate Nucleotidomimetic Inhibitors of hHint1.; Acs Med.Chem.Lett., 7:780-784, 2016; PubMed: 27563403; DOI: 10.1021/acsmedchemlett.6b00169

Experimental method

X-RAY DIFFRACTION (1.25 Å)