5IH9

MELK in complex with NVS-MELK8A

5IH9 の概要

• エントリーDOI: 10.2210/pdb5ih9/pdb
• 関連するPDBエントリー: 5HIA 5HIC 5IH8
• 分子名称: Maternal embryonic leucine zipper kinase, 1-methyl-4-[4-(4-{3-[(piperidin-4-yl)methoxy]pyridin-4-yl}-1H-pyrazol-1-yl)phenyl]piperazine (3 entities in total)
• 機能のキーワード: kinase uba domain inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cell membrane ; Peripheral membrane protein : Q14680
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 39391.64

構造登録者

Sprague, E.R.,Puleo, D.E. (登録日: 2016-02-29, 公開日: 2016-06-01, 最終更新日: 2024-03-06)

• 主引用文献: Toure, B.B.,Giraldes, J.,Smith, T.,Sprague, E.R.,Wang, Y.,Mathieu, S.,Chen, Z.,Mishina, Y.,Feng, Y.,Yan-Neale, Y.,Shakya, S.,Chen, D.,Meyer, M.,Puleo, D.,Brazell, J.T.,Straub, C.,Sage, D.,Wright, K.,Yuan, Y.,Chen, X.,Duca, J.,Kim, S.,Tian, L.,Martin, E.,Hurov, K.,Shao, W.; Toward the Validation of Maternal Embryonic Leucine Zipper Kinase: Discovery, Optimization of Highly Potent and Selective Inhibitors, and Preliminary Biology Insight.; J.Med.Chem., 59:4711-4723, 2016; PubMed: 27187609; DOI: 10.1021/acs.jmedchem.6b00052

実験手法

X-RAY DIFFRACTION (1.79 Å)