5IA0

Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with alisertib (MLN8237)

Summary for 5IA0

DescriptorEphrin type-A receptor 2, alisertib, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywordstransferase, tyrosine-protein kinase, receptor, atp-binding
Biological sourceHomo sapiens (Human)
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Total number of polymer chains3
Total molecular weight106186.65
Authors
Kudlinzki, D.,Linhard, V.L.,Gande, S.L.,Sreeramulu, S.,Saxena, K.,Heinzlmeir, S.,Medard, G.,Kuester, B.,Schwalbe, H. (deposition date: 2016-02-21, release date: 2016-11-09, Last modification date: 2019-06-12)
Primary citation
Heinzlmeir, S.,Kudlinzki, D.,Sreeramulu, S.,Klaeger, S.,Gande, S.L.,Linhard, V.,Wilhelm, M.,Qiao, H.,Helm, D.,Ruprecht, B.,Saxena, K.,Medard, G.,Schwalbe, H.,Kuster, B.
Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs.
ACS Chem. Biol., 11:3400-3411, 2016
PubMed: 27768280 (PDB entries with the same primary citation)
DOI: 10.1021/acschembio.6b00709
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.948 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.22440 1.0% 5.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution