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5IA0

Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with alisertib (MLN8237)

Functional Information from GO Data
ChainGOidnamespacecontents
A0004672molecular_functionprotein kinase activity
A0004713molecular_functionprotein tyrosine kinase activity
A0005524molecular_functionATP binding
A0006468biological_processprotein phosphorylation
B0004672molecular_functionprotein kinase activity
B0004713molecular_functionprotein tyrosine kinase activity
B0005524molecular_functionATP binding
B0006468biological_processprotein phosphorylation
C0004672molecular_functionprotein kinase activity
C0004713molecular_functionprotein tyrosine kinase activity
C0005524molecular_functionATP binding
C0006468biological_processprotein phosphorylation
Functional Information from PDB Data
site_idAC1
Number of Residues16
Detailsbinding site for residue A5B A 1001
ChainResidue
AILE619
ALYS702
ALEU746
ASER756
AHOH1110
AHOH1157
AHOH1171
AHOH1182
AALA621
AALA644
ALYS646
AGLU663
ATYR694
AMET695
AGLU696
AGLY698

site_idAC2
Number of Residues2
Detailsbinding site for residue EDO A 1002
ChainResidue
ALYS617
ATYR694

site_idAC3
Number of Residues5
Detailsbinding site for residue EDO A 1003
ChainResidue
AALA731
ALYS863
APHE864
AALA865
AHOH1106

site_idAC4
Number of Residues2
Detailsbinding site for residue EDO A 1004
ChainResidue
AASN750
AHOH1258

site_idAC5
Number of Residues6
Detailsbinding site for residue EDO A 1005
ChainResidue
AGLN852
AARG860
APRO862
AEDO1006
CASP888
CARG890

site_idAC6
Number of Residues4
Detailsbinding site for residue EDO A 1006
ChainResidue
AARG861
ALYS863
AASP866
AEDO1005

site_idAC7
Number of Residues5
Detailsbinding site for residue EDO A 1007
ChainResidue
AHIS672
AALA725
ALYS728
AHOH1178
AHOH1210

site_idAC8
Number of Residues17
Detailsbinding site for residue A5B B 1001
ChainResidue
BILE619
BALA621
BALA644
BLYS646
BGLU663
BTYR694
BMET695
BGLU696
BGLY698
BLYS702
BASN744
BLEU746
BSER756
BHOH1153
BHOH1157
BHOH1164
BHOH1222

site_idAC9
Number of Residues2
Detailsbinding site for residue EDO B 1002
ChainResidue
BARG835
CGLN616

site_idAD1
Number of Residues6
Detailsbinding site for residue EDO B 1003
ChainResidue
AGLN616
ALYS617
BASN750
BHOH1106
BHOH1156
BHOH1274

site_idAD2
Number of Residues5
Detailsbinding site for residue EDO B 1004
ChainResidue
BARG705
BASP708
BTHR812
BTYR813
BHOH1176

site_idAD3
Number of Residues5
Detailsbinding site for residue EDO B 1005
ChainResidue
BGLU693
BTYR694
BMET695
BGLU696
BASN748

site_idAD4
Number of Residues4
Detailsbinding site for residue EDO B 1006
ChainResidue
BARG705
BGLU706
BHOH1115
BHOH1125

site_idAD5
Number of Residues5
Detailsbinding site for residue EDO B 1007
ChainResidue
BPHE670
BARG677
BLEU678
BHOH1136
BHOH1141

site_idAD6
Number of Residues2
Detailsbinding site for residue EDO B 1008
ChainResidue
BLYS617
BILE619

site_idAD7
Number of Residues4
Detailsbinding site for residue EDO B 1009
ChainResidue
BVAL601
BLEU602
BLYS603
BPHE604

site_idAD8
Number of Residues5
Detailsbinding site for residue EDO B 1010
ChainResidue
BALA731
BLYS863
BPHE864
BALA865
BHOH1172

site_idAD9
Number of Residues18
Detailsbinding site for residue A5B C 1001
ChainResidue
CTYR694
CMET695
CGLU696
CGLY698
CLYS702
CARG743
CASN744
CLEU746
CSER756
CEDO1003
CHOH1101
CHOH1120
CHOH1134
CHOH1194
CILE619
CALA621
CALA644
CLYS646

site_idAE1
Number of Residues7
Detailsbinding site for residue EDO C 1002
ChainResidue
CPHE604
CTHR605
CTHR606
CGLY668
CLEU678
CGLU679
CGLY680

site_idAE2
Number of Residues6
Detailsbinding site for residue EDO C 1003
ChainResidue
CLYS617
CILE619
CTYR694
CA5B1001
CHOH1121
CHOH1134

site_idAE3
Number of Residues1
Detailsbinding site for residue EDO C 1004
ChainResidue
CARG738

site_idAE4
Number of Residues5
Detailsbinding site for residue EDO C 1005
ChainResidue
CALA731
CLYS863
CPHE864
CALA865
CHOH1165

site_idAE5
Number of Residues3
Detailsbinding site for residue EDO C 1006
ChainResidue
AASP888
CGLN852
CARG860

Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues28
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGAGEFGEVYkGmlktssgkkevp......VAIK
ChainResidueDetails
AILE619-LYS646

site_idPS00109
Number of Residues13
DetailsPROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. YVHrDLAARNILV
ChainResidueDetails
ATYR735-VAL747

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028
ChainResidueDetails
AASP739
BASP739
CASP739

site_idSWS_FT_FI2
Number of Residues6
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
ChainResidueDetails
AILE619
ALYS646
BILE619
BLYS646
CILE619
CLYS646

site_idSWS_FT_FI3
Number of Residues3
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:19369195
ChainResidueDetails
ATYR628
BTYR628
CTYR628

site_idSWS_FT_FI4
Number of Residues3
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195
ChainResidueDetails
ATHR647
BTHR647
CTHR647

site_idSWS_FT_FI5
Number of Residues3
DetailsMOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000250|UniProtKB:Q03145
ChainResidueDetails
ATYR735
BTYR735
CTYR735

site_idSWS_FT_FI6
Number of Residues3
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q03145
ChainResidueDetails
ATYR772
BTYR772
CTYR772

site_idSWS_FT_FI7
Number of Residues3
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:19369195
ChainResidueDetails
ASER869
BSER869
CSER869

site_idSWS_FT_FI8
Number of Residues3
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER892
BSER892
CSER892

site_idSWS_FT_FI9
Number of Residues3
DetailsMOD_RES: Phosphoserine; by PKB/AKT1, RPS6KA1, RPS6KA3 AND PKA => ECO:0000269|PubMed:19573808, ECO:0000269|PubMed:26158630, ECO:0000269|PubMed:27385333, ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER897
BSER897
CSER897

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PDB entries from 2024-03-27

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