5IA0
Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with alisertib (MLN8237)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C | Ephrin type-A receptor 2 | polymer | 306 | 34462.8 | 3 | UniProt (P29317) Pfam (PF07714) In PDB | Homo sapiens (Human) | Epithelial cell kinase,Tyrosine-protein kinase receptor ECK |
2 | A, B, C | alisertib | non-polymer | 518.9 | 3 | Chemie (A5B) | |||
3 | A, B, C | 1,2-ETHANEDIOL | non-polymer | 62.1 | 20 | Chemie (EDO) | Homo sapiens | ||
4 | water | water | 18.0 | 518 | Chemie (HOH) |
Sequence modifications
A, B, C: 596 - 900 (UniProt: P29317)
PDB | External Database | Details |
---|---|---|
Gly 595 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 103388.5 | |
Non-Polymers* | Number of molecules | 23 |
Total formula weight | 2798.1 | |
All* | Total formula weight | 106186.7 |