5I7R

Mycobacterium tuberculosis CysM in complex with the Urea-scaffold inhibitor 2 [3-(3-([1,1'-biphenyl]-3-yl)ureido)benzoic acid]

Summary for 5I7R

Entry DOI	10.2210/pdb5i7r/pdb
Related	3DKI 3FGP
Descriptor	O-phosphoserine sulfhydrylase, PYRIDOXAL-5'-PHOSPHATE, 3-{[([1,1'-biphenyl]-3-yl)carbamoyl]amino}benzoic acid, ... (5 entities in total)
Functional Keywords	mycobacterium tuberculosis, cysteine biosynthesis, sulphur metabolism, inhibitor, lyase
Biological source	Mycobacterium tuberculosis
Total number of polymer chains	2
Total formula weight	70902.44
Authors	Schnell, R.,Maric, S.,Schneider, G. (deposition date: 2016-02-18, release date: 2016-08-17, Last modification date: 2024-01-10)
Primary citation	Brunner, K.,Maric, S.,Reshma, R.S.,Almqvist, H.,Seashore-Ludlow, B.,Gustavsson, A.L.,Poyraz, O.,Yogeeswari, P.,Lundback, T.,Vallin, M.,Sriram, D.,Schnell, R.,Schneider, G. Inhibitors of the Cysteine Synthase CysM with Antibacterial Potency against Dormant Mycobacterium tuberculosis. J.Med.Chem., 59:6848-6859, 2016 Cited by PubMed: 27379713 DOI: 10.1021/acs.jmedchem.6b00674 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.73 Å)

Structure validation