5I7R
Mycobacterium tuberculosis CysM in complex with the Urea-scaffold inhibitor 2 [3-(3-([1,1'-biphenyl]-3-yl)ureido)benzoic acid]
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (B, A) | O-phosphoserine sulfhydrylase | polymer | 326 | 34724.1 | 2 | UniProt (P9WP53) Pfam (PF00291) | Mycobacterium tuberculosis | OPS sulfhydrylase,CysO-thiocarboxylate-dependent cysteine synthase,Cysteine synthase B,CSase B,O-phosphoserine-specific cysteine synthase,[CysO sulfur-carrier protein]-thiocarboxylate-dependent cysteine synthase |
| 2 | C, H (B, A) | PYRIDOXAL-5'-PHOSPHATE | non-polymer | 247.1 | 2 | Chemie (PLP) | |||
| 3 | D, I (B, A) | 3-{[([1,1'-biphenyl]-3-yl)carbamoyl]amino}benzoic acid | non-polymer | 332.4 | 2 | Chemie (68W) | |||
| 4 | E, F, G, J, K (B, A) | ACETATE ION | non-polymer | 59.0 | 5 | Chemie (ACT) | |||
| 5 | L, M (B, A) | water | water | 18.0 | 209 | Chemie (HOH) |
Sequence modifications
B, A: 1 - 323 (UniProt: P9WP53)
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| His 0 | - | expression tag |
| Ala 2 | Thr 2 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 69448.2 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1454.2 | |
| All* | Total formula weight | 70902.4 |
