5I7R
Mycobacterium tuberculosis CysM in complex with the Urea-scaffold inhibitor 2 [3-(3-([1,1'-biphenyl]-3-yl)ureido)benzoic acid]
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004124 | molecular_function | cysteine synthase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006535 | biological_process | cysteine biosynthetic process from serine |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| A | 0019344 | biological_process | cysteine biosynthetic process |
| A | 0030170 | molecular_function | pyridoxal phosphate binding |
| A | 0032991 | cellular_component | protein-containing complex |
| A | 0033847 | molecular_function | O-phosphoserine sulfhydrylase activity |
| B | 0004124 | molecular_function | cysteine synthase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006535 | biological_process | cysteine biosynthetic process from serine |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| B | 0019344 | biological_process | cysteine biosynthetic process |
| B | 0030170 | molecular_function | pyridoxal phosphate binding |
| B | 0032991 | cellular_component | protein-containing complex |
| B | 0033847 | molecular_function | O-phosphoserine sulfhydrylase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | binding site for residue PLP B 401 |
| Chain | Residue |
| B | LYS51 |
| B | ALA294 |
| B | ASP295 |
| B | 68W402 |
| B | HOH510 |
| B | HOH548 |
| B | HOH564 |
| B | ASN81 |
| B | GLY182 |
| B | GLY184 |
| B | THR185 |
| B | THR186 |
| B | GLY187 |
| B | THR188 |
| B | SER265 |
| site_id | AC2 |
| Number of Residues | 19 |
| Details | binding site for residue 68W B 402 |
| Chain | Residue |
| B | LYS51 |
| B | GLY80 |
| B | ASN81 |
| B | THR82 |
| B | GLY184 |
| B | ALA208 |
| B | PRO210 |
| B | ALA218 |
| B | ARG220 |
| B | VAL242 |
| B | ALA247 |
| B | ILE264 |
| B | SER265 |
| B | ALA268 |
| B | PLP401 |
| B | HOH514 |
| B | HOH538 |
| B | HOH539 |
| B | HOH569 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue ACT B 403 |
| Chain | Residue |
| A | LEU7 |
| A | PRO46 |
| B | ASP43 |
| B | ARG44 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue ACT B 404 |
| Chain | Residue |
| A | TRP298 |
| B | ASN45 |
| B | PRO46 |
| B | GLY48 |
| B | HOH571 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue ACT B 405 |
| Chain | Residue |
| B | THR78 |
| B | SER79 |
| B | TYR152 |
| B | ASN221 |
| B | HOH514 |
| site_id | AC6 |
| Number of Residues | 18 |
| Details | binding site for residue 68W A 402 |
| Chain | Residue |
| A | LYS51 |
| A | THR78 |
| A | SER79 |
| A | ASN81 |
| A | THR82 |
| A | GLN151 |
| A | TYR152 |
| A | GLY182 |
| A | GLY184 |
| A | ALA208 |
| A | PRO210 |
| A | VAL242 |
| A | ALA247 |
| A | ILE264 |
| A | SER265 |
| A | ALA268 |
| A | PLP401 |
| A | HOH564 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue ACT A 403 |
| Chain | Residue |
| A | ASP43 |
| A | ASN45 |
| A | PRO46 |
| A | GLY48 |
| A | HOH524 |
| B | TRP298 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue ACT A 404 |
| Chain | Residue |
| A | LEU41 |
| A | ASP43 |
| A | ARG44 |
| B | LEU7 |
| B | PRO46 |
| site_id | AC9 |
| Number of Residues | 22 |
| Details | binding site for Di-peptide PLP A 401 and LYS A 51 |
| Chain | Residue |
| A | SER49 |
| A | ILE50 |
| A | ASP52 |
| A | ARG53 |
| A | PRO54 |
| A | ALA55 |
| A | ASN81 |
| A | THR82 |
| A | SER85 |
| A | GLY182 |
| A | GLY184 |
| A | THR185 |
| A | THR186 |
| A | GLY187 |
| A | THR188 |
| A | SER265 |
| A | ALA294 |
| A | ASP295 |
| A | 68W402 |
| A | HOH519 |
| A | HOH540 |
| A | HOH542 |
Functional Information from PROSITE/UniProt
| site_id | PS00901 |
| Number of Residues | 19 |
| Details | CYS_SYNTHASE Cysteine synthase/cystathionine beta-synthase P-phosphate attachment site. KlEdrn.PTgSIKdRpAvrM |
| Chain | Residue | Details |
| B | LYS40-MET58 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:18771296, ECO:0000269|PubMed:18799456, ECO:0000269|PubMed:19101553 |
| Chain | Residue | Details |
| B | ASN81 | |
| B | SER265 | |
| A | ASN81 | |
| A | SER265 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: |
| Chain | Residue | Details |
| B | GLY184 | |
| A | GLY184 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000305 |
| Chain | Residue | Details |
| B | ARG220 | |
| A | ARG220 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-(pyridoxal phosphate)lysine |
| Chain | Residue | Details |
| B | LYS51 | |
| A | LYS51 |
