5HSR

Fluorine substituted 5-methyl-6-(3',4'-difluoromethoxyphenythio)thieno[2,3-d]pyrimidine-2,4-diamine

Summary for 5HSR

Related5HSU
DescriptorDihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-methyl-6-[(2,3,4-trifluorophenyl)sulfanyl]thieno[2,3-d]pyrimidine-2,4-diamine, ... (4 entities in total)
Functional Keywordsdihydrofolate reductase inhibitor complex with nadph, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological sourceHomo sapiens (Human)
Cellular locationMitochondrion  P00374
Total number of polymer chains1
Total molecular weight22779.67
Authors
Cody, V. (deposition date: 2016-01-26, release date: 2017-02-01, Last modification date: 2017-09-27)
Primary citation
Cody, V.,Gangjee, A.
Human dihydrofolate reductase ternary complex with a series of fluorine substituted 5-methyl-6-phenythio)thieno[2,3-d]pyrimidine-2,4-diamines
To Be Published,
Experimental method
X-RAY DIFFRACTION (1.21 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.2151001.8%6.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution