5HSU

Fluorine substituted 5-methyl-6-(2',4'-difluoromethoxyphenythio)thieno[2,3-d]pyrimidine-2,4-diamine

Summary for 5HSU

• Entry DOI: 10.2210/pdb5hsu/pdb
• Related: 5HSR
• Descriptor: Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-methyl-6-[(2,3,4-trifluorophenyl)sulfanyl]thieno[2,3-d]pyrimidine-2,4-diamine, ... (4 entities in total)
• Functional Keywords: dihydrofolate reductase inhibitor complex with nadph, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Mitochondrion : P00374
• Total number of polymer chains: 1
• Total formula weight: 22437.31

Authors

Cody, V. (deposition date: 2016-01-26, release date: 2017-02-01, Last modification date: 2023-09-27)

• Primary citation: Cody, V.,Gangjee, A.; Human dihydrofolate reductase ternary complex with a series of fluorine substituted 5-methyl-6-phenythio)thieno[2,3-d]pyrimidine-2,4-diamines; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.46 Å)