5HGG

Crystal structure of uPA in complex with a camelid-derived antibody fragment

Summary for 5HGG

Entry DOI	10.2210/pdb5hgg/pdb
Descriptor	Urokinase-type plasminogen activator, Camelid Derived Antibody Fragment, Nb4, GLYCEROL, ... (7 entities in total)
Functional Keywords	upa, nanobody, serine protease, hydrolase-inhibitor complex, hydrolase/inhibitor
Biological source	Homo sapiens (Human) More
Cellular location	Secreted: P00749
Total number of polymer chains	4
Total formula weight	84538.65
Authors	Yung, K.W.Y.,Kromann-Hansen, T.,Andreasen, P.A.,Ngo, J.C.K. (deposition date: 2016-01-08, release date: 2016-06-01, Last modification date: 2016-08-10)
Primary citation	Kromann-Hansen, T.,Oldenburg, E.,Yung, K.W.,Ghassabeh, G.H.,Muyldermans, S.,Declerck, P.J.,Huang, M.,Andreasen, P.A.,Ngo, J.C. A Camelid-derived Antibody Fragment Targeting the Active Site of a Serine Protease Balances between Inhibitor and Substrate Behavior J.Biol.Chem., 291:15156-15168, 2016 Cited by PubMed: 27226628 DOI: 10.1074/jbc.M116.732503 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.97 Å)

Structure validation