5H4J

Crystal structure of Human dUTPase in complex with N-[(1R)-1-[3-(Cyclopentyloxy)-phenyl]-ethyl]-3-[(3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)methoxy]-1-propanesulfonamide

Summary for 5H4J

• Entry DOI: 10.2210/pdb5h4j/pdb
• Descriptor: Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial, N-[(1R)-1-[3-(Cyclopentyloxy)-phenyl]-ethyl]-3-[(3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)methoxy]-1-propanesulfonamide, ZINC ION, ... (6 entities in total)
• Functional Keywords: hydrolase, hydrolase inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 18435.23

Authors

Chong, K.T.,Miyahara, S.,Miyakoshi, H.,Fukuoka, M. (deposition date: 2016-11-01, release date: 2017-11-01, Last modification date: 2023-11-08)

• Primary citation: Yano, W.,Yokogawa, T.,Wakasa, T.,Yamamura, K.,Fujioka, A.,Yoshisue, K.,Matsushima, E.,Miyahara, S.,Miyakoshi, H.,Taguchi, J.,Chong, K.T.,Takao, Y.,Fukuoka, M.,Matsuo, K.; TAS-114, a First-in-Class Dual dUTPase/DPD Inhibitor, Demonstrates Potential to Improve Therapeutic Efficacy of Fluoropyrimidine-Based Chemotherapy.; Mol. Cancer Ther., 17:1683-1693, 2018; PubMed: 29748212; DOI: 10.1158/1535-7163.MCT-17-0911

Experimental method

X-RAY DIFFRACTION (1.8 Å)