5H4J

Crystal structure of Human dUTPase in complex with N-[(1R)-1-[3-(Cyclopentyloxy)-phenyl]-ethyl]-3-[(3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)methoxy]-1-propanesulfonamide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0004170	molecular_function	dUTP diphosphatase activity
A	0006226	biological_process	dUMP biosynthetic process
A	0046081	biological_process	dUTP catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	binding site for residue FKM A 201

Chain	Residue
A	VAL65
A	VAL109
A	GLY110
A	VAL112
A	HOH354
A	HOH390
A	HOH401
A	SER86
A	GLY87
A	ALA90
A	ALA98
A	GLY99
A	VAL100
A	TYR105
A	ASN108

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site_id	AC2
Number of Residues	3
Details	binding site for residue ZN A 202

Chain	Residue
A	GLU33
A	HIS34
A	IMD203

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site_id	AC3
Number of Residues	6
Details	binding site for residue IMD A 203

Chain	Residue
A	GLU33
A	HIS34
A	TYR54
A	ZN202
A	HOH347
A	HOH385

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site_id	AC4
Number of Residues	1
Details	binding site for residue DMS A 204

Chain	Residue
A	HIS92

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:8805593, ECO:0000305|PubMed:17880943, ECO:0007744|PDB:1Q5H, ECO:0007744|PDB:2HQU, ECO:0007744|PDB:3EHW

Chain	Residue	Details
A	ARG85
A	ARG153
A	PHE158

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site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:8805593, ECO:0000305|PubMed:17880943, ECO:0007744|PDB:1Q5H, ECO:0007744|PDB:2HQU, ECO:0007744|PDB:3ARA, ECO:0007744|PDB:3ARN, ECO:0007744|PDB:3EHW

Chain	Residue	Details
A	GLY99
A	GLY110

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
A	LEU88

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER11

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