5H4J
Crystal structure of Human dUTPase in complex with N-[(1R)-1-[3-(Cyclopentyloxy)-phenyl]-ethyl]-3-[(3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)methoxy]-1-propanesulfonamide
Summary for 5H4J
Entry DOI | 10.2210/pdb5h4j/pdb |
Descriptor | Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial, N-[(1R)-1-[3-(Cyclopentyloxy)-phenyl]-ethyl]-3-[(3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)methoxy]-1-propanesulfonamide, ZINC ION, ... (6 entities in total) |
Functional Keywords | hydrolase, hydrolase inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 18435.23 |
Authors | Chong, K.T.,Miyahara, S.,Miyakoshi, H.,Fukuoka, M. (deposition date: 2016-11-01, release date: 2017-11-01, Last modification date: 2023-11-08) |
Primary citation | Yano, W.,Yokogawa, T.,Wakasa, T.,Yamamura, K.,Fujioka, A.,Yoshisue, K.,Matsushima, E.,Miyahara, S.,Miyakoshi, H.,Taguchi, J.,Chong, K.T.,Takao, Y.,Fukuoka, M.,Matsuo, K. TAS-114, a First-in-Class Dual dUTPase/DPD Inhibitor, Demonstrates Potential to Improve Therapeutic Efficacy of Fluoropyrimidine-Based Chemotherapy. Mol. Cancer Ther., 17:1683-1693, 2018 Cited by PubMed: 29748212DOI: 10.1158/1535-7163.MCT-17-0911 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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