5FUZ
Extending the half-life of a Fab fragment through generation of a humanised anti-Human Serum Albumin (HSA) Fv domain: an investigation into the correlation between affinity and serum half-life
Summary for 5FUZ
Entry DOI | 10.2210/pdb5fuz/pdb |
Related | 5FUO |
Descriptor | 645 FAB, HEAVY CHAIN, 645 FAB, LIGHT CHAIN (3 entities in total) |
Functional Keywords | immune system, anti-albumin, fab fragment, serum half-life, fcrn, human serum albumin |
Biological source | HOMO SAPIENS (HUMAN) More |
Total number of polymer chains | 2 |
Total formula weight | 48320.82 |
Authors | |
Primary citation | Adams, R.,Griffin, L.,Compson, J.E.,Jairaj, M.,Baker, T.,Ceska, T.,West, S.,Zaccheo, O.,Dave, E.,Lawson, A.D.G.,Humphreys, D.P.,Heywood, S. Extending the Half-Life of a Fab Fragment Through Generation of a Humanized Anti-Human Serum Albumin Fv Domain: An Investigation Into the Correlation between Affinity and Serum Half-Life. Mabs, 8:1336-, 2016 Cited by PubMed: 27315033DOI: 10.1080/19420862.2016.1185581 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.68 Å) |
Structure validation
Download full validation report