5FSA
Crystal structure of sterol 14-alpha demethylase (CYP51) from a pathogenic yeast Candida albicans in complex with the antifungal drug posaconazole
Summary for 5FSA
Entry DOI | 10.2210/pdb5fsa/pdb |
Related | 5TZI |
Descriptor | CYP51 VARIANT1, PROTOPORPHYRIN IX CONTAINING FE, POSACONAZOLE, ... (4 entities in total) |
Functional Keywords | cytochrome p450, heme, oxidoreductase, monooxygenase, sterol biosynthesis, eukaryotic membranes, cytochrome p450 fold, endoplasmic reticulum membrane, oxidoreductase-oxidoreductase inhibitor complex |
Biological source | CANDIDA ALBICANS |
Total number of polymer chains | 2 |
Total formula weight | 115504.90 |
Authors | Hargrove, T.Y.,Wawrzak, Z.,Friggeri, L.,Lepesheva, G.I. (deposition date: 2016-01-02, release date: 2017-03-15, Last modification date: 2024-01-10) |
Primary citation | Hargrove, T.Y.,Friggeri, L.,Wawrzak, Z.,Qi, A.,Hoekstra, W.J.,Schotzinger, R.J.,York, J.D.,Guengerich, F.P.,Lepesheva, G.I. Structural analyses of Candida albicans sterol 14 alpha-demethylase complexed with azole drugs address the molecular basis of azole-mediated inhibition of fungal sterol biosynthesis. J. Biol. Chem., 292:6728-6743, 2017 Cited by PubMed: 28258218DOI: 10.1074/jbc.M117.778308 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.86 Å) |
Structure validation
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