5FRN
Crystal structure of the Prototype Foamy Virus (PFV) intasome in complex with magnesium and the INSTI XZ419 (compound 4c)
Summary for 5FRN
Entry DOI | 10.2210/pdb5frn/pdb |
Related | 5FRM 5FRO |
Descriptor | Integrase, 5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP *TP*CP*GP*CP*A)-3', 5'-D(*TP*GP*CP*GP*AP*AP*AP*TP*TP*CP*CP*AP*TP*GP *AP*CP*A)-3', ... (9 entities in total) |
Functional Keywords | recombination, viral protein/dna, protein-dna complex, tetramer, dna integration, endonuclease, metal-binding, multifunctional enzyme, nuclease, nucleotidyltransferase, nucleus, transferase, viral nucleoprotein, virion, dna- binding, zinc binding, hhcc motif, viral protein, inhibitor, dna-binding protein-dna complex |
Biological source | Human spumaretrovirus (SFVcpz(hu)) More |
Total number of polymer chains | 4 |
Total formula weight | 101522.90 |
Authors | Maskell, D.P.,Pye, V.E.,Cherepanov, P. (deposition date: 2015-12-18, release date: 2016-02-17, Last modification date: 2024-01-10) |
Primary citation | Zhao, X.Z.,Smith, S.J.,Maskell, D.P.,Metifiot, M.,Pye, V.E.,Fesen, K.,Marchand, C.,Pommier, Y.,Cherepanov, P.,Hughes, S.H.,Burke, T.R.J. HIV-1 Integrase Strand Transfer Inhibitors with Reduced Susceptibility to Drug Resistant Mutant Integrases. Acs Chem.Biol., 11:1074-, 2016 Cited by PubMed: 26808478DOI: 10.1021/ACSCHEMBIO.5B00948 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.85 Å) |
Structure validation
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