5FRN
Crystal structure of the Prototype Foamy Virus (PFV) intasome in complex with magnesium and the INSTI XZ419 (compound 4c)
5FRN の概要
エントリーDOI | 10.2210/pdb5frn/pdb |
関連するPDBエントリー | 5FRM 5FRO |
分子名称 | Integrase, 5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP *TP*CP*GP*CP*A)-3', 5'-D(*TP*GP*CP*GP*AP*AP*AP*TP*TP*CP*CP*AP*TP*GP *AP*CP*A)-3', ... (9 entities in total) |
機能のキーワード | recombination, viral protein/dna, protein-dna complex, tetramer, dna integration, endonuclease, metal-binding, multifunctional enzyme, nuclease, nucleotidyltransferase, nucleus, transferase, viral nucleoprotein, virion, dna- binding, zinc binding, hhcc motif, viral protein, inhibitor, dna-binding protein-dna complex |
由来する生物種 | Human spumaretrovirus (SFVcpz(hu)) 詳細 |
タンパク質・核酸の鎖数 | 4 |
化学式量合計 | 101522.90 |
構造登録者 | |
主引用文献 | Zhao, X.Z.,Smith, S.J.,Maskell, D.P.,Metifiot, M.,Pye, V.E.,Fesen, K.,Marchand, C.,Pommier, Y.,Cherepanov, P.,Hughes, S.H.,Burke, T.R.J. HIV-1 Integrase Strand Transfer Inhibitors with Reduced Susceptibility to Drug Resistant Mutant Integrases. Acs Chem.Biol., 11:1074-, 2016 Cited by PubMed: 26808478DOI: 10.1021/ACSCHEMBIO.5B00948 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.85 Å) |
構造検証レポート
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