5FDR
Mcl-1 complexed with small molecule inhibitor
Summary for 5FDR
Entry DOI | 10.2210/pdb5fdr/pdb |
Related | 4HW2 |
Descriptor | Induced myeloid leukemia cell differentiation protein Mcl-1, 5-[[6-chloranyl-3-[3-(4-chloranyl-3,5-dimethyl-phenoxy)propyl]-7-(3,5-dimethyl-1~{H}-pyrazol-4-yl)-1~{H}-indol-2-yl]carbonylsulfamoyl]furan-2-carboxylic acid (2 entities in total) |
Functional Keywords | mcl-1, inhibitor, apoptosis-apoptosis inhibitor complex, apoptosis/apoptosis inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 74499.62 |
Authors | Zhao, B. (deposition date: 2015-12-16, release date: 2016-03-02, Last modification date: 2023-09-27) |
Primary citation | Pelz, N.F.,Bian, Z.,Zhao, B.,Shaw, S.,Tarr, J.C.,Belmar, J.,Gregg, C.,Camper, D.V.,Goodwin, C.M.,Arnold, A.L.,Sensintaffar, J.L.,Friberg, A.,Rossanese, O.W.,Lee, T.,Olejniczak, E.T.,Fesik, S.W. Discovery of 2-Indole-acylsulfonamide Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods. J.Med.Chem., 59:2054-2066, 2016 Cited by PubMed: 26878343DOI: 10.1021/acs.jmedchem.5b01660 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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