5FDR
Mcl-1 complexed with small molecule inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | Induced myeloid leukemia cell differentiation protein Mcl-1 | polymer | 158 | 17965.4 | 4 | UniProt (Q07820) Pfam (PF00452) In PDB | Homo sapiens (Human) | Bcl-2-like protein 3,Bcl2-L-3,Bcl-2-related protein EAT/mcl1,mcl1/EAT |
| 2 | A, B, C, D | 5-[[6-chloranyl-3-[3-(4-chloranyl-3,5-dimethyl-phenoxy)propyl]-7-(3,5-dimethyl-1~{H}-pyrazol-4-yl)-1~{H}-indol-2-yl]carbonylsulfamoyl]furan-2-carboxylic acid | non-polymer | 659.5 | 4 | Chemie (5X3) |
Sequence modifications
A, B, C, D: 172 - 327 (UniProt: Q07820)
| PDB | External Database | Details |
|---|---|---|
| Gly 170 | - | expression tag |
| Asp 171 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 71861.5 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 2638.1 | |
| All* | Total formula weight | 74499.6 |
