5EW3

Human Vascular Endothelial Growth Factor Receptor 2 (KDR) Kinase Domain in complex with AAL993

5EW3 の概要

• エントリーDOI: 10.2210/pdb5ew3/pdb
• 分子名称: Vascular endothelial growth factor receptor 2, 2-(pyridin-4-ylmethylamino)-~{N}-[3-(trifluoromethyl)phenyl]benzamide (3 entities in total)
• 機能のキーワード: kdr, kinase domain, atp-binding site, vegfr2 inhibitors, transferase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cell junction . Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted . Isoform 3: Secreted: P35968
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 73132.24

構造登録者

Stark, W.,Goepfert, A. (登録日: 2015-11-20, 公開日: 2015-12-16, 最終更新日: 2024-01-10)

• 主引用文献: Bold, G.,Schnell, C.,Furet, P.,McSheehy, P.,Bruggen, J.,Mestan, J.,Manley, P.W.,Druckes, P.,Burglin, M.,Durler, U.,Loretan, J.,Reuter, R.,Wartmann, M.,Theuer, A.,Bauer-Probst, B.,Martiny-Baron, G.,Allegrini, P.,Goepfert, A.,Wood, J.,Littlewood-Evans, A.; A Novel Potent Oral Series of VEGFR2 Inhibitors Abrogate Tumor Growth by Inhibiting Angiogenesis.; J.Med.Chem., 59:132-146, 2016; PubMed: 26629594; DOI: 10.1021/acs.jmedchem.5b01582

実験手法

X-RAY DIFFRACTION (2.5 Å)