5EUQ
Crystal structure of an engineered construct of phosphatidylinositol 4 kinase III beta with a potent and selective inhibitor in complex with GDP loaded Rab11
Summary for 5EUQ
Entry DOI | 10.2210/pdb5euq/pdb |
Descriptor | Ras-related protein Rab-11A, Phosphatidylinositol 4-kinase beta, GUANOSINE-5'-DIPHOSPHATE, ... (5 entities in total) |
Functional Keywords | lipid kinase, gtpase complex, transferase-signaling protein complex, transferase/signaling protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 86500.59 |
Authors | Burke, J.E.,Fowler, M.L. (deposition date: 2015-11-19, release date: 2016-02-24, Last modification date: 2023-09-27) |
Primary citation | Rutaganira, F.U.,Fowler, M.L.,McPhail, J.A.,Gelman, M.A.,Nguyen, K.,Xiong, A.,Dornan, G.L.,Tavshanjian, B.,Glenn, J.S.,Shokat, K.M.,Burke, J.E. Design and Structural Characterization of Potent and Selective Inhibitors of Phosphatidylinositol 4 Kinase III beta. J.Med.Chem., 59:1830-1839, 2016 Cited by PubMed: 26885694DOI: 10.1021/acs.jmedchem.5b01311 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.2 Å) |
Structure validation
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