5EUQ

Crystal structure of an engineered construct of phosphatidylinositol 4 kinase III beta with a potent and selective inhibitor in complex with GDP loaded Rab11

5EUQ の概要

• エントリーDOI: 10.2210/pdb5euq/pdb
• 分子名称: Ras-related protein Rab-11A, Phosphatidylinositol 4-kinase beta, GUANOSINE-5'-DIPHOSPHATE, ... (5 entities in total)
• 機能のキーワード: lipid kinase, gtpase complex, transferase-signaling protein complex, transferase/signaling protein
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 86500.59

構造登録者

Burke, J.E.,Fowler, M.L. (登録日: 2015-11-19, 公開日: 2016-02-24, 最終更新日: 2023-09-27)

• 主引用文献: Rutaganira, F.U.,Fowler, M.L.,McPhail, J.A.,Gelman, M.A.,Nguyen, K.,Xiong, A.,Dornan, G.L.,Tavshanjian, B.,Glenn, J.S.,Shokat, K.M.,Burke, J.E.; Design and Structural Characterization of Potent and Selective Inhibitors of Phosphatidylinositol 4 Kinase III beta.; J.Med.Chem., 59:1830-1839, 2016; PubMed: 26885694; DOI: 10.1021/acs.jmedchem.5b01311

実験手法

X-RAY DIFFRACTION (3.2 Å)