5EU9

Structure of Human Enolase 2 in complex with ((3S,5S)-1,5-dihydroxy-3-methyl-2-oxopyrrolidin-3-yl)phosphonic acid

Summary for 5EU9

• Entry DOI: 10.2210/pdb5eu9/pdb
• Related: 1TE6 2AKM 2AKZ 3UCC 3UCD 3UJE 3UJF 3UJR 3UJS 4ZA0 4ZCW
• Descriptor: Gamma-enolase, MAGNESIUM ION, ((3S,5S)-1,5-dihydroxy-3-methyl-2-oxopyrrolidin-3-yl)phosphonic acid, ... (5 entities in total)
• Functional Keywords: enolase gamma, glycolysis, neuron specific enolase, carbohydrate metabolism, lyase-lyase inhibitor complex, lyase/lyase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 8
• Total formula weight: 388172.96

Authors

Leonard, P.G.,Muller, F.L. (deposition date: 2015-11-18, release date: 2016-11-23, Last modification date: 2023-09-27)

• Primary citation: Leonard, P.G.,Maxwell, D.,Satani, N.,Peng, Z.,Link, T.,Lee, G.,Bosajou, A.,Sun, D.,Lin, Y.E.,DiFrancesco, M.E.,Czako, B.,Wang, Y.A.,Bornmann, W.,DePhinho, R.A.,Muller, F.L.; SF2312, a natural phosphonate inhibitor of Enolase; To be Published,

Experimental method

X-RAY DIFFRACTION (2.047 Å)