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5ESO

Crystal Structure of M. tuberculosis MenD with ThDP, Mg2+ and Isochorismate bound

Summary for 5ESO
Entry DOI10.2210/pdb5eso/pdb
Related5ERX 5ERY 5ESD 5ESS 5ESU
Descriptor2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, MAGNESIUM ION, (5S,6S)-5-[(1-carboxyethenyl)oxy]-6-hydroxycyclohexa-1,3-diene-1-carboxylic acid, ... (8 entities in total)
Functional Keywordsmenaquinone biosynthesis, mend, 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1-carboxylate synthase, thiamin-diphosphate dependent enzyme, pyruvate oxidase family, transferase
Biological sourceMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Total number of polymer chains4
Total formula weight242384.69
Authors
Johnston, J.M.,Jirgis, E.N.M.,Bashiri, G.,Bulloch, E.M.M.,Baker, E.N. (deposition date: 2015-11-16, release date: 2016-06-22, Last modification date: 2024-05-01)
Primary citationJirgis, E.N.,Bashiri, G.,Bulloch, E.M.,Johnston, J.M.,Baker, E.N.
Structural Views along the Mycobacterium tuberculosis MenD Reaction Pathway Illuminate Key Aspects of Thiamin Diphosphate-Dependent Enzyme Mechanisms.
Structure, 24:1167-1177, 2016
Cited by
PubMed: 27291649
DOI: 10.1016/j.str.2016.04.018
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.05 Å)
Structure validation

221051

数据于2024-06-12公开中

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