5ESO
Crystal Structure of M. tuberculosis MenD with ThDP, Mg2+ and Isochorismate bound
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0009234 | biological_process | menaquinone biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0030145 | molecular_function | manganese ion binding |
| A | 0030976 | molecular_function | thiamine pyrophosphate binding |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0070204 | molecular_function | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0009234 | biological_process | menaquinone biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0030145 | molecular_function | manganese ion binding |
| B | 0030976 | molecular_function | thiamine pyrophosphate binding |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0070204 | molecular_function | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity |
| C | 0000287 | molecular_function | magnesium ion binding |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0009234 | biological_process | menaquinone biosynthetic process |
| C | 0016740 | molecular_function | transferase activity |
| C | 0030145 | molecular_function | manganese ion binding |
| C | 0030976 | molecular_function | thiamine pyrophosphate binding |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0070204 | molecular_function | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity |
| D | 0000287 | molecular_function | magnesium ion binding |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0009234 | biological_process | menaquinone biosynthetic process |
| D | 0016740 | molecular_function | transferase activity |
| D | 0030145 | molecular_function | manganese ion binding |
| D | 0030976 | molecular_function | thiamine pyrophosphate binding |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0070204 | molecular_function | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 601 |
| Chain | Residue |
| A | ASP440 |
| A | ASP469 |
| A | HOH823 |
| A | HOH835 |
| A | HOH899 |
| A | HOH904 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | binding site for residue ISC A 602 |
| Chain | Residue |
| A | THR78 |
| A | ARG107 |
| A | ASN117 |
| A | GLN118 |
| A | HOH736 |
| A | HOH758 |
| D | ARG282 |
| D | ARG381 |
| D | LEU478 |
| A | GLY28 |
| A | SER29 |
| A | ARG30 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue FMT A 603 |
| Chain | Residue |
| A | ARG97 |
| A | THR299 |
| A | PRO305 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 604 |
| Chain | Residue |
| A | THR245 |
| A | VAL246 |
| A | ALA247 |
| A | ARG253 |
| A | PRO258 |
| A | LEU259 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 605 |
| Chain | Residue |
| A | GLU140 |
| A | ALA142 |
| A | THR146 |
| A | LEU149 |
| A | TRP153 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue MG B 601 |
| Chain | Residue |
| B | ASP440 |
| B | ASP469 |
| B | GLY471 |
| B | FMT604 |
| B | HOH701 |
| B | HOH850 |
| site_id | AC7 |
| Number of Residues | 13 |
| Details | binding site for residue ISC B 602 |
| Chain | Residue |
| B | GLY28 |
| B | SER29 |
| B | ARG30 |
| B | THR78 |
| B | ARG107 |
| B | GLN118 |
| B | HOH711 |
| B | HOH786 |
| B | HOH832 |
| C | ARG282 |
| C | ARG381 |
| C | LEU478 |
| C | TPP605 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue FMT B 603 |
| Chain | Residue |
| B | GLU140 |
| B | ALA142 |
| B | THR146 |
| B | TRP153 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue FMT B 604 |
| Chain | Residue |
| B | GLY439 |
| B | ASP440 |
| B | LEU441 |
| B | THR442 |
| B | MG601 |
| B | HOH701 |
| site_id | AD1 |
| Number of Residues | 7 |
| Details | binding site for residue GOL B 605 |
| Chain | Residue |
| B | THR245 |
| B | ALA247 |
| B | ARG253 |
| B | PRO258 |
| B | LEU259 |
| B | HOH713 |
| B | HOH738 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue MG C 601 |
| Chain | Residue |
| C | ASP440 |
| C | ASP469 |
| C | GLY471 |
| C | TPP605 |
| C | HOH730 |
| site_id | AD3 |
| Number of Residues | 6 |
| Details | binding site for residue FMT C 602 |
| Chain | Residue |
| B | ASN117 |
| C | ALA376 |
| C | SER377 |
| C | ARG381 |
| C | ARG399 |
| C | ALA402 |
| site_id | AD4 |
| Number of Residues | 2 |
| Details | binding site for residue FMT C 603 |
| Chain | Residue |
| C | ARG394 |
| C | ARG396 |
| site_id | AD5 |
| Number of Residues | 5 |
| Details | binding site for residue FMT C 604 |
| Chain | Residue |
| C | ILE393 |
| C | ARG394 |
| C | VAL395 |
| C | ARG396 |
| C | HOH741 |
| site_id | AD6 |
| Number of Residues | 25 |
| Details | binding site for residue TPP C 605 |
| Chain | Residue |
| C | LEU441 |
| C | THR442 |
| C | ASP469 |
| C | GLY471 |
| C | GLY472 |
| C | GLY473 |
| C | ILE474 |
| C | PHE475 |
| C | MG601 |
| C | HOH730 |
| C | HOH731 |
| C | HOH824 |
| B | PRO27 |
| B | GLU55 |
| B | THR81 |
| B | ISC602 |
| C | SER377 |
| C | ASN378 |
| C | PRO379 |
| C | ALA402 |
| C | GLY403 |
| C | ILE404 |
| C | ASP405 |
| C | GLY439 |
| C | ASP440 |
| site_id | AD7 |
| Number of Residues | 7 |
| Details | binding site for residue BME C 606 |
| Chain | Residue |
| C | LEU25 |
| C | CYS26 |
| C | GLU55 |
| C | ALA58 |
| C | ALA76 |
| C | ALA82 |
| C | LEU86 |
| site_id | AD8 |
| Number of Residues | 5 |
| Details | binding site for residue MG D 601 |
| Chain | Residue |
| D | ASP440 |
| D | ASP469 |
| D | GLY471 |
| D | TPP602 |
| D | HOH715 |
| site_id | AD9 |
| Number of Residues | 21 |
| Details | binding site for residue TPP D 602 |
| Chain | Residue |
| A | PRO27 |
| A | GLU55 |
| A | HOH813 |
| D | SER377 |
| D | ASN378 |
| D | PRO379 |
| D | ALA402 |
| D | GLY403 |
| D | ILE404 |
| D | ASP405 |
| D | GLY439 |
| D | ASP440 |
| D | LEU441 |
| D | THR442 |
| D | ASP469 |
| D | GLY471 |
| D | GLY472 |
| D | GLY473 |
| D | ILE474 |
| D | MG601 |
| D | HOH715 |
| site_id | AE1 |
| Number of Residues | 6 |
| Details | binding site for residue BME D 603 |
| Chain | Residue |
| D | LEU25 |
| D | CYS26 |
| D | ALA76 |
| D | MET77 |
| D | THR78 |
| D | ALA82 |
