5ESO
Crystal Structure of M. tuberculosis MenD with ThDP, Mg2+ and Isochorismate bound
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000287 | molecular_function | magnesium ion binding |
A | 0005886 | cellular_component | plasma membrane |
A | 0009234 | biological_process | menaquinone biosynthetic process |
A | 0016740 | molecular_function | transferase activity |
A | 0030145 | molecular_function | manganese ion binding |
A | 0030976 | molecular_function | thiamine pyrophosphate binding |
A | 0046872 | molecular_function | metal ion binding |
A | 0070204 | molecular_function | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity |
B | 0000287 | molecular_function | magnesium ion binding |
B | 0005886 | cellular_component | plasma membrane |
B | 0009234 | biological_process | menaquinone biosynthetic process |
B | 0016740 | molecular_function | transferase activity |
B | 0030145 | molecular_function | manganese ion binding |
B | 0030976 | molecular_function | thiamine pyrophosphate binding |
B | 0046872 | molecular_function | metal ion binding |
B | 0070204 | molecular_function | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity |
C | 0000287 | molecular_function | magnesium ion binding |
C | 0005886 | cellular_component | plasma membrane |
C | 0009234 | biological_process | menaquinone biosynthetic process |
C | 0016740 | molecular_function | transferase activity |
C | 0030145 | molecular_function | manganese ion binding |
C | 0030976 | molecular_function | thiamine pyrophosphate binding |
C | 0046872 | molecular_function | metal ion binding |
C | 0070204 | molecular_function | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity |
D | 0000287 | molecular_function | magnesium ion binding |
D | 0005886 | cellular_component | plasma membrane |
D | 0009234 | biological_process | menaquinone biosynthetic process |
D | 0016740 | molecular_function | transferase activity |
D | 0030145 | molecular_function | manganese ion binding |
D | 0030976 | molecular_function | thiamine pyrophosphate binding |
D | 0046872 | molecular_function | metal ion binding |
D | 0070204 | molecular_function | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 6 |
Details | binding site for residue MG A 601 |
Chain | Residue |
A | ASP440 |
A | ASP469 |
A | HOH823 |
A | HOH835 |
A | HOH899 |
A | HOH904 |
site_id | AC2 |
Number of Residues | 12 |
Details | binding site for residue ISC A 602 |
Chain | Residue |
A | THR78 |
A | ARG107 |
A | ASN117 |
A | GLN118 |
A | HOH736 |
A | HOH758 |
D | ARG282 |
D | ARG381 |
D | LEU478 |
A | GLY28 |
A | SER29 |
A | ARG30 |
site_id | AC3 |
Number of Residues | 3 |
Details | binding site for residue FMT A 603 |
Chain | Residue |
A | ARG97 |
A | THR299 |
A | PRO305 |
site_id | AC4 |
Number of Residues | 6 |
Details | binding site for residue GOL A 604 |
Chain | Residue |
A | THR245 |
A | VAL246 |
A | ALA247 |
A | ARG253 |
A | PRO258 |
A | LEU259 |
site_id | AC5 |
Number of Residues | 5 |
Details | binding site for residue GOL A 605 |
Chain | Residue |
A | GLU140 |
A | ALA142 |
A | THR146 |
A | LEU149 |
A | TRP153 |
site_id | AC6 |
Number of Residues | 6 |
Details | binding site for residue MG B 601 |
Chain | Residue |
B | ASP440 |
B | ASP469 |
B | GLY471 |
B | FMT604 |
B | HOH701 |
B | HOH850 |
site_id | AC7 |
Number of Residues | 13 |
Details | binding site for residue ISC B 602 |
Chain | Residue |
B | GLY28 |
B | SER29 |
B | ARG30 |
B | THR78 |
B | ARG107 |
B | GLN118 |
B | HOH711 |
B | HOH786 |
B | HOH832 |
C | ARG282 |
C | ARG381 |
C | LEU478 |
C | TPP605 |
site_id | AC8 |
Number of Residues | 4 |
Details | binding site for residue FMT B 603 |
Chain | Residue |
B | GLU140 |
B | ALA142 |
B | THR146 |
B | TRP153 |
site_id | AC9 |
Number of Residues | 6 |
Details | binding site for residue FMT B 604 |
Chain | Residue |
B | GLY439 |
B | ASP440 |
B | LEU441 |
B | THR442 |
B | MG601 |
B | HOH701 |
site_id | AD1 |
Number of Residues | 7 |
Details | binding site for residue GOL B 605 |
Chain | Residue |
B | THR245 |
B | ALA247 |
B | ARG253 |
B | PRO258 |
B | LEU259 |
B | HOH713 |
B | HOH738 |
site_id | AD2 |
Number of Residues | 5 |
Details | binding site for residue MG C 601 |
Chain | Residue |
C | ASP440 |
C | ASP469 |
C | GLY471 |
C | TPP605 |
C | HOH730 |
site_id | AD3 |
Number of Residues | 6 |
Details | binding site for residue FMT C 602 |
Chain | Residue |
B | ASN117 |
C | ALA376 |
C | SER377 |
C | ARG381 |
C | ARG399 |
C | ALA402 |
site_id | AD4 |
Number of Residues | 2 |
Details | binding site for residue FMT C 603 |
Chain | Residue |
C | ARG394 |
C | ARG396 |
site_id | AD5 |
Number of Residues | 5 |
Details | binding site for residue FMT C 604 |
Chain | Residue |
C | ILE393 |
C | ARG394 |
C | VAL395 |
C | ARG396 |
C | HOH741 |
site_id | AD6 |
Number of Residues | 25 |
Details | binding site for residue TPP C 605 |
Chain | Residue |
C | LEU441 |
C | THR442 |
C | ASP469 |
C | GLY471 |
C | GLY472 |
C | GLY473 |
C | ILE474 |
C | PHE475 |
C | MG601 |
C | HOH730 |
C | HOH731 |
C | HOH824 |
B | PRO27 |
B | GLU55 |
B | THR81 |
B | ISC602 |
C | SER377 |
C | ASN378 |
C | PRO379 |
C | ALA402 |
C | GLY403 |
C | ILE404 |
C | ASP405 |
C | GLY439 |
C | ASP440 |
site_id | AD7 |
Number of Residues | 7 |
Details | binding site for residue BME C 606 |
Chain | Residue |
C | LEU25 |
C | CYS26 |
C | GLU55 |
C | ALA58 |
C | ALA76 |
C | ALA82 |
C | LEU86 |
site_id | AD8 |
Number of Residues | 5 |
Details | binding site for residue MG D 601 |
Chain | Residue |
D | ASP440 |
D | ASP469 |
D | GLY471 |
D | TPP602 |
D | HOH715 |
site_id | AD9 |
Number of Residues | 21 |
Details | binding site for residue TPP D 602 |
Chain | Residue |
A | PRO27 |
A | GLU55 |
A | HOH813 |
D | SER377 |
D | ASN378 |
D | PRO379 |
D | ALA402 |
D | GLY403 |
D | ILE404 |
D | ASP405 |
D | GLY439 |
D | ASP440 |
D | LEU441 |
D | THR442 |
D | ASP469 |
D | GLY471 |
D | GLY472 |
D | GLY473 |
D | ILE474 |
D | MG601 |
D | HOH715 |
site_id | AE1 |
Number of Residues | 6 |
Details | binding site for residue BME D 603 |
Chain | Residue |
D | LEU25 |
D | CYS26 |
D | ALA76 |
D | MET77 |
D | THR78 |
D | ALA82 |